Metabolism Diazepam is N-demethylated by CYP3A4 and 2C19 on the Energetic metabolite N-desmethyldiazepam, and it is hydroxylated by CYP3A4 towards the Lively metabolite temazepam.Recommend both equally individuals and caregivers in regards to the risks of respiratory despair and sedation when diazepam is utilised with opioids. Recommend sufferers t